Proton magnetic resonance spectroscopy (1H-MRS) as a potential tool to predict overall survival in diffuse midline glioma

Author

Esther L. Pavao

Date

2024

Document Type

Thesis

Degree Name

Master of Science

Department

Biomedical Engineering

Committee Chair

Aaryani Sajja

Committee Member

Puneet Bagga

Committee Member

Richard Smith

Abstract

Proton magnetic resonance spectroscopy (1H-MRS) offers a reliable clinically feasible tool for non-invasive monitoring of tumor metabolism. However, methods for analyzing tumor metabolism using 1H-MRS often lack standardization and rely heavily on manual data processing. This study used 1H-MRS to non-invasively quantify tumor metabolites associated with dysregulated metabolic pathways in patients diagnosed with diffuse intrinsic pontine glioma (DIPG). 1H-MRS technique allowed for the identification of specific metabolic alterations to DIPG that could potentially offer insights into disease progression and therapeutic targets. Utilizing advanced biomedical engineering tools and techniques, we calculated median overall survival lengths at specific metabolic thresholds. The analysis revealed certain metabolic ratios exhibited significant associations with patient overall survival, suggesting their potential utility as prognostic indicators for cancer patients.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to ProQuest.

Notes

Open Access

Recommended Citation

Pavao, Esther L., "Proton magnetic resonance spectroscopy (1H-MRS) as a potential tool to predict overall survival in diffuse midline glioma" (2024). Electronic Theses and Dissertations. 3564.
https://digitalcommons.memphis.edu/etd/3564