![Electronic Theses and Dissertations](../../assets/md5images/959896c1313a336188aaeb2e7c01e19f.jpg)
Electronic Theses and Dissertations
Date
2024
Document Type
Thesis
Degree Name
Master of Science
Department
Biomedical Engineering
Committee Chair
Aaryani Sajja
Committee Member
Puneet Bagga
Committee Member
Richard Smith
Abstract
Proton magnetic resonance spectroscopy (1H-MRS) offers a reliable clinically feasible tool for non-invasive monitoring of tumor metabolism. However, methods for analyzing tumor metabolism using 1H-MRS often lack standardization and rely heavily on manual data processing. This study used 1H-MRS to non-invasively quantify tumor metabolites associated with dysregulated metabolic pathways in patients diagnosed with diffuse intrinsic pontine glioma (DIPG). 1H-MRS technique allowed for the identification of specific metabolic alterations to DIPG that could potentially offer insights into disease progression and therapeutic targets. Utilizing advanced biomedical engineering tools and techniques, we calculated median overall survival lengths at specific metabolic thresholds. The analysis revealed certain metabolic ratios exhibited significant associations with patient overall survival, suggesting their potential utility as prognostic indicators for cancer patients.
Library Comment
Dissertation or thesis originally submitted to ProQuest.
Notes
Open Access
Recommended Citation
Pavao, Esther L., "Proton magnetic resonance spectroscopy (1H-MRS) as a potential tool to predict overall survival in diffuse midline glioma" (2024). Electronic Theses and Dissertations. 3564.
https://digitalcommons.memphis.edu/etd/3564
Comments
Data is provided by the student.