Date of Award
Master of Science
Electrical and Computer Engr
Bashir I Morshed
Eddie L Jacobs
Warren O Haggard
In recent years, pharmaceutical research has seen a surge in various smart drug delivery systems (DDS) that attempt dosage control and drug localization, thereby granting enhanced therapeutic capabilities and flexibility to healthcare providers. Some of them used a stimuli to modify the drug release profile from DDS. In this work, chitosan microbeads embedded with magnetic nanoparticles were loaded with tetracycline (tet.) antibiotic and stimulated by an alternating magnetic field for 60 min. The spectrophotometric analysis of the supernatant from these stimulated samples showed a significantly higher release of tet., as compared to the control samples, which were subjected to exact same environment without the stimulation. Interestingly, the release was higher only during the stimulation period, the resting period showed comparable amount of tet. released in the waiting span. The results indicate promising possibility of a smart controllable DDS by magnetic excitation.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Mohapatra, Ankita, "Magnetic Stimulus Responsive Tetracycline Delivery System Based on Chitosan Microbeads with Embedded Magnetic Nanoparticles" (2015). Electronic Theses and Dissertations. 1135.