Date of Award
Master of Science
Marie van der Merwe
This study aimed to determine if a dietary intervention of fish oil could reduce the risk of metabolic syndrome phenotype associated with glucocorticoids (GC), given as part of the acute lymphocytic leukemia (ALL) treatment. Weaned C57BL/6 male mice were assigned either a standard rodent chow or Western-type diets containing 45% calories from fat consisting of lard (high omega-6/low omega-3 fatty acids). At six weeks of age, GC treatment was given daily for 28 days to half the mice in each diet group. Mice on the lard diet either remained on this diet or were switched to an isocaloric diet containing 45% fat from fish oil (high omega-3/low omega-6 fatty acids). Our data showed that the fish oil diet (high in omega-3 fatty acids) reduced body mass gain, fatty liver development, and glucose tolerance when used in combination with high dose GC therapy. The data suggests that consuming more omega-3 fatty acids than omega-6 fatty acids might reduce the metabolic syndrome phenotype associated with ALL treatment.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Beech, LeeAnna Allyson, "Effect of a Dietary Intervention on Glucocorticoid-Induced Metabolic Syndrome" (2015). Electronic Theses and Dissertations. 1287.