Master of Science
Gary Lee Bowlin
Marko Z Radic
Richard A Smith
Electrospinning, a fabrication technique used to create non-woven, porous templates from natural and synthetic polymers, is commonly used in tissue engineering because it is highly tailorable. However, traditional electrospinning creates restrictive pore sizes that limit the required cell migration. Therefore, tissue engineering groups have sought to enhance and regulate porosity of tissue engineering templates. Air-impedance electrospinning generates templates with tailorable, patterned areas of low and high density fiber deposition. In this preliminary study, polydioxanone and polydioxanone/fibrinogen air-impedance electrospun templates are fabricated and evaluated. This work demonstrates an improved air-impedance electrospinning system, consisting of a newly designed funnel equipped to hold changeable porous deposition plates and administer air flow in a confined and focused manner, with parameters that significantly increase porosity and maintain template integrity. These results are critical to template integrity and efficacy as parameters can be further optimized to induce the desired template porosity, strength, and texture fora given application.
Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Selders, Gretchen Schreyack, "Fabrication and Characterization of Air-Impedance Electrospun Tissue Regeneration Templates" (2016). Electronic Theses and Dissertations. 1512.