Date of Award
Master of Science
The alignment of short reads to genomes is an important part of many computational tasks that utilize next-generation sequencing data, including assembling of reads into genomes, genotyping, and measuring gene expression. Although recent technological advances have produced increasingly higher quality data, the complexity of genomes places an inherent limitation on how effectively short-read aligners can perform. Thus, there is a need to investigate the extent to which genomic complexity affects the performance of short-read aligners.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Gao, Shanshan, "How Genome Complexity Can Explain the Hardness of Aligning Reads to Genomes" (2016). Electronic Theses and Dissertations. 1523.