Date of Award
Master of Science
Marie Van der Merwe
Background: Medulloblastoma is the most common type of pediatric bran cancer and accounts for 20% of all diagnosed brain tumors. The aims of this research were to describe the nutrition status patterns and nutrition related compications occuring during treatment of children diagnosed with medulloblastoma and to identify specific time points in treatment for the initation of proactive therapy. Design: A retrospective study of 60 patients who were treated on a one treatment protocol, Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma (SJMB12). Nutrition assessments, nutrition-related adverse events and nutrition intervention strategies were recorded at the initiation and completion of each cycle treatment. Results: The majority of the participants (in all strata) had at least mild malnutrition (80% among W1 patients, 75% for S1/S2 patients, 91% for N1 patients and 94% for N2/N3 patients). Nearly 75% of patients received an appetite stimulant and 62% required EN or PN. Grade 3 and higher anorexia was observed in approximately 20% of the patients. Conclusion: This current study demonstrates that children with medulloblastoma have significant malnutrition exacerbated by disease state, treatment and chemotherapy=related adverse events. A pattern of declining nutrition status emerged in all stratums of medulloblastoma early on in treatment.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Boone, Kimberly Afton, "Medulloblastoma: Identifying High Risk Time Points during Treatment for Development of Nutrition Deficits" (2016). Electronic Theses and Dissertations. 1555.