Date of Award
Master of Science
Studies into how genetic modifications affect bone development may help research into new treatments for bone diseases. In order to understand whether these treatments are effective, bones should be mechanically evaluated, because ultimately they support large mechanical loads. Three-point bend testing has been widely utilized in the mechanical evaluation of whole, long bones since these bones fail mostly in bending. The accuracy of the mechanical properties obtained from these tests using the Euler-Bernoulli beam equations is questionable; due to the complexity of the bending mechanics of long bones. Therefore, in this work, a correction factor approach was utilized to measure , correct, and compare the elastic modulus of femurs of mice with one of three genetic modifications to that of the control group. Experiments and parametric finite element models were utilized to show that statistically significant differences exist among the bones from one of the genetic groups compared to the others.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Buechel, Meagan Maureen, "A Comparison of Elastic Modulii of Femurs from Genetically Modified Mice: Three-Point Bending Experiments and a Correction Factor Approach" (2011). Electronic Theses and Dissertations. 168.