Electronic Theses and Dissertations

Identifier

5999

Date

2017

Date of Award

7-15-2017

Document Type

Thesis

Degree Name

Master of Science

Major

Biomedical Engineering

Committee Chair

Jessica Amber Jennings

Committee Member

Warren O. Haggard

Committee Member

Joel D. Bumgardner

Abstract

Periprosthetic joint infection (PJI) is a major burden on the healthcare system and significantly increases the mortality rate of patients following total joint arthroplasty. Prophylactic local antibiotic delivery can reduce infection rates and improve patient outcome; however, infection rates remain at 1-2%. Biofilm inhibitors are a possible means to prevent bacterial attachment to implants. This work evaluates the use of a phosphatidylcholine coating for local delivery of antibiotics and a biofilm inhibitor, cis-2-decenoic acid. Results show that antibiotic and biofilm inhibitor are released at clinically relevant amounts for 5-9 days, indicating the phospholipid is a viable carrier. In vitro studies suggest that the coatings are cytocompatible at relevant drug loading concentrations, and a pilot in vivo model of PJI indecates that these coatings significantly increase the rate of bacterial clearance in contaminated surgical wounds. Pending further investigation, phosphatidylcholine may have clinical usefulness as a prophylactic drug delivery coating on implants.

Comments

Data is provided by the student.

Library Comment

dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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