Date of Award
Master of Science
Jessica Amber Jennings
Warren O. Haggard
Joel D. Bumgardner
Periprosthetic joint infection (PJI) is a major burden on the healthcare system and significantly increases the mortality rate of patients following total joint arthroplasty. Prophylactic local antibiotic delivery can reduce infection rates and improve patient outcome; however, infection rates remain at 1-2%. Biofilm inhibitors are a possible means to prevent bacterial attachment to implants. This work evaluates the use of a phosphatidylcholine coating for local delivery of antibiotics and a biofilm inhibitor, cis-2-decenoic acid. Results show that antibiotic and biofilm inhibitor are released at clinically relevant amounts for 5-9 days, indicating the phospholipid is a viable carrier. In vitro studies suggest that the coatings are cytocompatible at relevant drug loading concentrations, and a pilot in vivo model of PJI indecates that these coatings significantly increase the rate of bacterial clearance in contaminated surgical wounds. Pending further investigation, phosphatidylcholine may have clinical usefulness as a prophylactic drug delivery coating on implants.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Harris, Michael Anthony, "Evaluation of Phosphatidylcholine as a Local Drug Delivery Device for Application to Orthopedic Implants" (2017). Electronic Theses and Dissertations. 1693.