Date of Award
Master of Science
It has been postulated that the high temperature reached during the polymerization of acrylic bone (for some brands, as high as 85 oC) (Tmax) may cause thermal necrosis of tissues close to the implant. In the present work, two methods to reducing Tmax were studied: change to the composition of the cement powder (by addition of 5-25 wt./wt.% microencapsulated phase change material) and a change to the composition of the cement liquid (by addition of a 1-3 vol./vol.% chain-stopping agent, namely, dodecyl mercaptan). The control cement was a commercially-available gentamicin-loaded brand. All cements were vacuum mixed. Eight other clinically-relevant properties of the cement were determined and compared to those of the control cement. While each method led to significant decreases in Tmax, the effect on the other cement properties varied to different degrees. Overall, the cements containing 2 vol./vol.% DDM and 3 vol./vol.% DDM may have the greatest potential to being viable alternatives to the control cement.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
McKee, Robert Baker, "Influence two Compositional Changes on In Vitro Properties of an Antibiotic-Loaded Acrylic Bone Cement" (2017). Electronic Theses and Dissertations. 1738.