Electronic Theses and Dissertations

Identifier

6176

Date

2018

Document Type

Thesis

Degree Name

Master of Science

Major

Electrical and Computer Engr

Concentration

Computer Engineering

Committee Member

Dr. Madhusudhanan Balasubramanian

Committee Member

Dr. Hasan Ali

Committee Member

Prof. Thomas Wyatt

Abstract

We present a computational model of sustained delivery of ocular pressure-lowering drugs (Timolol Maleate) to the anterior segment of the eye using drug infused contact lens. Ocular structures, aqueous humor flow and their interaction were modeled as linearly elastic solids, viscous fluid flow and fluid-structure interaction (FSI) respectively in COMSOL 5.3 as axisymmetric models. Timolol distribution from contact lens was modeled as transport of diluted species coupled with the flow dynamics (FSI velocity coupled). Aqueous humor production in the ciliary body was simulated as an inlet with a mass flow rate of 5e-8 kg/s. Over a 10-hour duration, drug transport was simulated using the diffusion-FSI coupled model and a model without FSI coupling. The coupled model provided a more accurate characterization of the drug transport and distribution. The model may be useful to study ocular drugs and their delivery to the anterior and posterior segment of the eye more accurately.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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