Date of Award
Master of Science
Children diagnosed with attention-deficit/hyperactivity disorder often suffer from impulsivity. The attenuated expression of latrophilin 3 (Lphn3) gene is linked to a dampening of extracellular dopamine (DA) levels that is consistent with the ADHD pathology expressed in humans, while this depletion of DA levels occurring as a result of Lphn3 variation also leads to impulsivity deficits that mirror those that are observed in humans sufferring from ADHD. The present study aimed to assess two different facets of impulsivity to offer a more complete assessment of the influence of Lphn3 variation on impulsive behavior. Compared to controls, Lphn3 knockout (KO) rats exhibited impulsive action deficits when assessed on a differential reinforcement of low rates (DRL) task. Compared to controls, Lphn3 KO rats did not demonstrate any clear deficits in impulsive choice when assessed on a delayed discounting (DD) task. Overall, these results suggest a dissociation in how Lphn3 variation affects impulsivity.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Nolen, Hunter Glen, "Impulsivity in the Lphn3 (Adgrl3) Knockout Rodent: Relevance to Attention-Deficit/Hyperactivity Disorder" (2019). Electronic Theses and Dissertations. 2035.