Date of Award
Master of Arts
Anti-depressants (ADs) appear not to work very well, and present a sequence of puzzling problems: side effects, a long latency period before recovery, an uncertain theoretical foundation for psychopharmacology, the high relative efficacy of placebos, and the generally low efficacy of ADs. Behind these empirical and scientific problems lie a host of ethical issues within drug development: publication bias, conflicts of interest, ghost authorship, and informed consent. I review these issues and find that: (1) there is no reason why ADs should be effective for humans, given their origin in rodent research; (2) the placebo effect rivals the drug effect, showing that ADs are ineffective; (3) drug companies andf doctors unethically continue to push the use of ADs; (4) analyses from science and the philosophy of science show that ADs are scientifically unsound; and (5) ethical analyses show that Ads are ethically intolerable.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Arnette, James Kenneth, "Of Mice and Medicine: An Examination of the Anti-Depressant Enterprise" (2020). Electronic Theses and Dissertations. 2093.