Electronic Theses and Dissertations

Identifier

6631

Date

2020

Date of Award

11-16-2020

Document Type

Thesis

Degree Name

Master of Science

Major

Biomedical Engineering

Committee Chair

Tao Lu Lowe

Committee Member

Richard Smith

Committee Member

Jessica Amber Jennings

Abstract

The goal of this thesis is to incorporate magnetic nanoparticles into nanogel systems to offer targeted and sustained drug delivery across biological barriers in response to a magnetic field in combination with magnetic imaging modality. Iron oxide magnetic nanoparticles were incorporated into thermo-responsive and biodegradable nanogels containing poly(N-isopropylacrylamide), dextran and lactate or ε-caprolactone oligomers during the nanogel synthesis by UV polymerization. The magnetization properties of the nanogels were measured by using a vibrating sample magnetometer. The results showed that the obtained magnetic nanogels were ferromagnetic, and the magnetization of nanogels increased with increasing the amount of iron oxide magnetic nanoparticles in the nanogels from 0 to 15 wt%. The saturated magnetization of the nanogels containing ε-caprolactone oligomers were two to four times higher than that of the corresponding nanogels containing lactate oligomers. MTS tests showed that the nanogels containing lactate or ε-caprolactone oligomers were not cytotoxic to NIH/3T3 at concentration up to 5 and 0.625 mg·mL-1, respectively with cell viability above 80%. When 10 wt% iron oxide nanoparticles were incorporated into the nanogels, the cell viability was increased. The successful completion of this project will have significant impact on long-lasting magnetic-stimulus-responsive therapy and diagnosis for many diseases.

Comments

Data is provided by the student.

Library Comment

dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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