Date of Award
Master of Science
Finite element models of the growth plate were created that included chondrocytes with primary cilia at different depths within the reserve zone (RZ) between the epiphyseal subchondral bone-plate (SBP) and proliferative zone (PZ). Cilia were oriented along the direction of bone growth. Loading was applied to include 10% compression or tension across the growth plate cartilage. Under compression, axial strains in the cilium body were compressive and increased with cell depth between the SBP (-20%) to the PZ (-40%); cilium membrane radial strains were compressive (-5%) near the SBP but became tensile (10%) near the PZ. Under distraction, axial strains in the cilium body were tensile and increased from the SBP (12%) to the PZ (28%); cilium membrane radial strains were tensile (4%) at the SBP but became compressive (-12%) at the PZ. Reserve zone chondrocyte cilia perceive amplified strains that are sensitive to cell depth and direction of loading.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Jimenez Carrion, Paola Michelle, "Finite Element Analysis and Modeling of the Reserve Zone Chondrocyte Cilium Response to Growth Plate Compression and Tension" (2021). Electronic Theses and Dissertations. 2176.