Electronic Theses and Dissertations

Identifier

6707

Date

2021

Date of Award

6-10-2021

Document Type

Thesis

Degree Name

Master of Science

Major

Biomedical Engineering

Committee Chair

John Williams

Committee Member

Jessica Jennings

Committee Member

Amy Curry

Abstract

Finite element models of the growth plate were created that included chondrocytes with primary cilia at different depths within the reserve zone (RZ) between the epiphyseal subchondral bone-plate (SBP) and proliferative zone (PZ). Cilia were oriented along the direction of bone growth. Loading was applied to include 10% compression or tension across the growth plate cartilage. Under compression, axial strains in the cilium body were compressive and increased with cell depth between the SBP (-20%) to the PZ (-40%); cilium membrane radial strains were compressive (-5%) near the SBP but became tensile (10%) near the PZ. Under distraction, axial strains in the cilium body were tensile and increased from the SBP (12%) to the PZ (28%); cilium membrane radial strains were tensile (4%) at the SBP but became compressive (-12%) at the PZ. Reserve zone chondrocyte cilia perceive amplified strains that are sensitive to cell depth and direction of loading.

Comments

Data is provided by the student.

Library Comment

dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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