Date of Award
Master of Science
Wilfried J. J. Karmaus
Asthma is adisease causing wheezing, difficulty breathing, and coughing. The studies regarding whether childhood asthma is transmitted by maternal asthma through the alteration of DNA methylation are novel. Epigenetic studies work with a large pool of potential predictors while the sample size is much smaller, usually is a few of hundreds. Therefore, given the feature of ultra-high dimensionality, investigators demand to reduce the number of variables to perform designed statistical analyses. Feature-selection methods are often used as a screening step for detecting the small subset of variables associated with an outcome of interest. Many epigenetic studies used either the Training-Testing Screening (ttScreening) or the Recursive Random Forest (RRF), however, the comparison of those two methods has not been discussed. Therefore, in this thesis, we compared the performance of ttScreening and RRF with simulation studies and applied to a real data example in identifying potential CpG sites at birth of the newborns in the transmission of asthma from asthmatic mothers to childhood asthma.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Pham, Ngan Thi Phuong, "Comparison And Application Of Screening Methods For Epigenome-wide Association Studies On Maternal And Childhood Asthma" (2021). Electronic Theses and Dissertations. 2184.