Electronic Theses and Dissertations

Identifier

1332

Date

2015

Document Type

Thesis (Access Restricted)

Degree Name

Master of Public Health

Major

Public Health

Concentration

Biostatistics

Committee Chair

Zhang Hongmei

Committee Member

Karmaus Wilfried

Committee Member

Pratik Banerjee

Abstract

Limited evidence has shown that DNA methylation plays a role in eczema. We explored the association between eczema and DNAmethylation on the epigenome-wide scale, to better understand epigenetics in eczema. 307,357 cytosine-phosphate-guanine sites (CpGs) in the first generation (F1) of Isle of Wight (IoW) cohort were screened via Random Forest (RF) ensemble for their potential association with eczema. Log-linear models followed by pathway analysis (DAVID) were performed in F1 and results were partially replicated in second generation of the cohort (F2). RF ensemble yielded 140 CpGs with potential association with eczema in F1. cg04850479 in PROZ showed an adjusted risk ratio (RR) of 15.10 (95% CI: 1.71 to 79.50) in F1 and 6.82 (95% CI: 1.52 to 30.62) in the F2 and cg01427769 in NEU1 showed an adjusted RR of 0.13 (95% CI: 0.03 to 0.46) in the F1 and 0.09 (95% CI: 0.03 to 0.36) in the F2

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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