Date of Award
Thesis (Access Restricted)
Master of Public Health
Limited evidence has shown that DNA methylation plays a role in eczema. We explored the association between eczema and DNAmethylation on the epigenome-wide scale, to better understand epigenetics in eczema. 307,357 cytosine-phosphate-guanine sites (CpGs) in the first generation (F1) of Isle of Wight (IoW) cohort were screened via Random Forest (RF) ensemble for their potential association with eczema. Log-linear models followed by pathway analysis (DAVID) were performed in F1 and results were partially replicated in second generation of the cohort (F2). RF ensemble yielded 140 CpGs with potential association with eczema in F1. cg04850479 in PROZ showed an adjusted risk ratio (RR) of 15.10 (95% CI: 1.71 to 79.50) in F1 and 6.82 (95% CI: 1.52 to 30.62) in the F2 and cg01427769 in NEU1 showed an adjusted RR of 0.13 (95% CI: 0.03 to 0.46) in the F1 and 0.09 (95% CI: 0.03 to 0.36) in the F2
Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Quraishi, Bilal Mohammed, "Identifying CpG Sites Associated With Eczema Via Random Forest Screening Of Epigenome-Wide Dna Methylation" (2015). Electronic Theses and Dissertations. 2257.