Electronic Theses and Dissertations

Identifier

84

Date

2010-06-23

Document Type

Thesis (Campus Access Only)

Degree Name

Master of Science

Major

Biomedical Engineering

Committee Chair

Eugene Eckstein

Committee Member

Khan Iftekharuddin

Abstract

The purpose of this project was to estimate renal volumes and to evaluate reliability of a model for estimating glomerular filtration rate (GFR) using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). Fourteen patients, who were long-term survivors of unilateral Wilms’ tumor, were included in the study. Renal volumes were estimated using segmentation techniques and the segmentation technique was tested for reproducibility. MR-GFR values were estimated using a modified two-compartmental (m2CD) model and other kinetic models from literature. Creatinine renal clearance and technetium 99mTc diethylene triamine pentaacetic acid (DTPA) serum clearance were used as reference GFR methods. All MR-GFR values were compared with the reference values to test the accuracy of different MR models. MR-GFR estimates using the m2CD model showed good correlation (r = 0.79) with the 99mTc-DTPA GFR compared to other models. Creatinine clearance measurements showed very poor correlation with both 99mTc-DTPA GFR and MR-GFR estimates.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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