Date of Award
Thesis (Campus Access Only)
Master of Science
The purpose of this project was to estimate renal volumes and to evaluate reliability of a model for estimating glomerular filtration rate (GFR) using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). Fourteen patients, who were long-term survivors of unilateral Wilms’ tumor, were included in the study. Renal volumes were estimated using segmentation techniques and the segmentation technique was tested for reproducibility. MR-GFR values were estimated using a modified two-compartmental (m2CD) model and other kinetic models from literature. Creatinine renal clearance and technetium 99mTc diethylene triamine pentaacetic acid (DTPA) serum clearance were used as reference GFR methods. All MR-GFR values were compared with the reference values to test the accuracy of different MR models. MR-GFR estimates using the m2CD model showed good correlation (r = 0.79) with the 99mTc-DTPA GFR compared to other models. Creatinine clearance measurements showed very poor correlation with both 99mTc-DTPA GFR and MR-GFR estimates.
Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Tipirneni, Aaryani, "Estimation of Renal Volumes and Glomerular Filtration Rate using Magnetic Resonance Imaging" (2010). Electronic Theses and Dissertations. 2323.