Date of Award
Master of Science
Vinhthuy T. Phan
Ebenezer O. George
This thesis studies various problems of analyzing microarray data with multiple treatments and multiple replicates using directed graphs. We start from a method that represents gene response as transitive directed acyclic graphs to extract meaningful information from microarray data (Phan et al., 2009). To extend this work, we simulate expressions of genes based on real data and make predictions about potential patterns of genes and their properties. From this, we predict whether such potential patterns are certain if given more replicates. Next, we used fold information which was not used in prior work to cluster genes share the same patterns and thus providing an additional layer of information. Finally, we created a web-based application to help other scientists try our method. The software assigns graphical patterns to genes and outputs images and textual data for further analyses.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Vo, Nam Sy, "Analysis of Microarray Data with Directed Graphs" (2011). Electronic Theses and Dissertations. 290.