Date of Award
Master of Science
Cellular senescence is characterized by a permanent exit from the cell cycle and the maintenance of a very active secretome termed the senescence-associated secretory phenotype (SASP). The accumulation of senescent cells has been associated with several age-related diseases, including cancer, atherosclerosis, osteoarthritis, pulmonary fibrosis, and neurodegenerative disorders such as Alzheimer's disease. For the past two decades, cellular senescence has been intensively studied, but exclusively on laboratory rodents and human cell lines. However, our understandings about cellular senescence in other species are extremely limited. This study aimed to characterize the SASP of long-lived and short-lived species using newly developed cutting-edge proteomic approach. Based on our findings, while some similarities were observed in the secretory profiles among most species, each species exhibited a unique SASP profile. Intriguingly, the SASP of the little brown bat, a species with maximum lifespan of 38 years, was markedly distinct from that of the other species. Our results suggest that there is a significant degree of variation in SASP among different species. This finding raises the significance of the interspecies differences in SASPs could contribute to the varying healthspan and lifespan observed across species.
Dissertation or thesis originally submitted to ProQuest
Shirazi, Joshua, "Characterization of cellular senescence in long-lived birds and mammals" (2023). Electronic Theses and Dissertations. 3078.