Date of Award
Master of Science
Since the common anaesthetic drug 2,6-diisopropylphenol (propofol) has a narrow physiological range, the administration of this drug could be improved through the development of a feedback-controlled delivery system. An evaluation of several carbon filaments was conducted to determine their capability to serve as the detecting element in such a system. Planar electrochemical cells (PECs) were fabricated with working electrodes made from three carbon filaments: Goodfellow (GF) carbon fibers, 11μm diameter; Bioanalytical Systems (BAS) carbon fibers, 9μm diameter; Specialty Materials (SM) glassy carbon monofilaments, 34.5μm diameter. The cells were used to make multiple, successive determinations of propofol – via cyclic voltammetry – in both pH ~7.0 aqueous and acetonitrile solutions. All three electrodes showed significant fouling in pH ~7.0 aqueous solutions. The SM electrodes had moderate fouling in acetonitrile solution, while both GF and BAS electrodes showed minimal fouling in acetonitrile solution.
Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Sheppard, James Bereman, "Evaluation of Carbon Filament Electrodes for Determination of 2,6-Diisopropylphenol (propofol) in Aqueous and Organic Solutions" (2011). Electronic Theses and Dissertations. 353.