Date of Award
Master of Science
Chemotherapy-induce mucositis (CIM) is a dose-limiting side effect of cancer therapy with concurrent nausea, vomiting, diarrhea, lethargy, and decreased food consumption. Of the pediatric population approximately 40% of patients receiving standard dose and 100% of patients receiving high dose chemotherapy are afflicted. Although scientific advancements have improved pediatric cancer survival rates, occurrence of mucositis decreases quality of life, increases treatment interruptions or even delays therapy, and often reduces the dose. Currently, there are no relevant animal models studying the entire gastrointestinal tract (GIT). Based on these findings, we decided to develop a novel porcine model for CIM. Examination of the entire GIT with coinciding clinical symptom, lead to the findings of CIM with the administration of single dose Doxorubicin, HCL (75mg/m2). A novel porcine CIM model will permit for an improved understanding of the disease process with regard to chemotherapy dosing and potential future intervention therapy.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Martin, Jamee Covington, "Chemotherapy Induced Mucositis: A Novel Porcine Model" (2011). Electronic Theses and Dissertations. 382.