Date of Award
Master of Science
Health and Sport Science
Exercise and Sport Science
Statins are widely used cholesterol loweing durgs that have shown to have many benefits. However, some studies have shown that statin treatment can lead to potential side effects, especially with exercise. We looked at the effects of a 21-day statin treatment on exercise performance in male Sprague Dawley rats. The rats were trained for 12 days and performed a maximal exercise test on the final day of the study. Time to exhaustion was used as the primary marker of performance and we noted a significant difference between the statin group and placebo group for time to exhaustion. Masses of heart, soleus muscle, and gastrocnemius muscle did not differ between the statin and placebo groups. Analyzation of blood sample showed a 17% reduction in cholesterol level in the statin group compared to the placebo group.
Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Kabir, Mohammad M., "Effects of a 21 Day Simvastatin Treatment on Exercise Performance in Sprague Dawley Rats" (2012). Electronic Theses and Dissertations. 582.