Date of Award
Master of Science
Hsiang H Lin
The purposes of the present work were to determine 1) the optimum amount of xylitol to use in a daptomycin-xylitol-Orthoset® 1 cement; and 2) the influence of xylitol on the elution mechanism of this cement. In support of these purposes, five properties of the xylitol-daptomycin-loaded cement (with four different xylitol loadings) were determined: daptomycin elution rate, daptomycin diffusion coefficient, index of the activity of the daptomycin eluate against S. aureus, rate of polymerization of the cement at 37ºC, and diffusion coefficient of phosphate buffered saline into the cement specimen. It was found that the optimum xylitol loading is 4 wt./wt.% (equivalent to 2 g of xylitol mixed with 1.4 g of daptomycin and 40 g of cement powder) and, regardless of the amount of xylitol in the cement, the applicable daptomycin elution mechanism is initial burst followed by slow Fickian release.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Salehi, Ali, "Influence of Xylitol on Properties of a Daptomycin-Loaded Acrylic Bone Cement" (2012). Electronic Theses and Dissertations. 589.