Date of Award
Master of Science
Teong E Tan
Hsiang Hsi Lin
The literature on the interaction effects of explanatory variables on properties of injectable bone cements used in the vertebral augmentation procedures of vertebroplasty and ballon kyphoplasty is sparse. In the present work, response surface methodology was used to investigate the direct and interaction effects of variables on three properties of a poly (methyl methacrylate) bone cement (maximum exotherm temperature, residual monomer content (RMC), and degradability) and three properites of a calcium phosphate cement (CPC) (injectability, final setting time (F), and compressive strength). Some main findings were 1) interaction effects were statistically significant for some properties, such as F, but not for others, such as RMC; and 2) values of variables that led to optimum or minimum cement properties; for example, optimum injectability of a CPC (98%) could be attained using a cement with a poly(ethylene glycol) content of 20 wt/wt% and prepared using a powder-to-liquid ratio of 2.0 g mL-1.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Werdofa, Daniel Mamushet, "Optimization of Properties of Injectable Bone Cement for Vertebral Augmentation Procedures: Application of Response Surface Methodology" (2013). Electronic Theses and Dissertations. 748.