Date of Award
Master of Science
Analyzing the interaction between the lipid membranes and nanoparticles helps to determine beneficial and harmful effects of nanoparticles on cells. Since the point of entry of cells is their plasma membrane, interactions between nanorods and lipid membranes were studied using molecular dynamics simulations. The effect of nanorods on membrane morphology was investigated systematically as a function of nanorods interaction with the lipid membrane, their surface coverage and number surface density. Our results indicate that when adsorbed on the membrane, the nanorods may cluster into chains and may lead to strong membrane deformations due to curvature driven interaction between nanorods. At particular nanorod-lipid interaction, single nanorod internalizes into the membrane via endocytosis. This happens to minimize the energy cost due to high bending of the membrane. At high nanorods' density and large nanorods' size it was found that the nanorods lead to membrane lysis which can be attributed to high surface coverage of nanorods.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Shrestha, Niraj, "Computer Simulations of Nanorods Interaction With Lipid Membrane" (2013). Electronic Theses and Dissertations. 772.