Electronic Theses and Dissertations





Document Type


Degree Name

Master of Science


Biomedical Engineering

Committee Member

Amy de Jongh Curry

Committee Member

Jack Buchanan

Committee Member

Eugene Eckstein


The analysis of heart rate variability (HRV) has become an increasingly popular and important tool for studying many disease pathologies in the past twenty years. HRV analyses are methods used to non-invasively quantify variability within heart rate. Purposes of this study were to design, evaluate, and apply an easy to use and open-source HRV analysis software package (HRVAS). HRVAS implements four major categories of HRV techniques: statistical and time-domain analysis, frequency-domain analysis, nonlinear analysis, and time-frequency analysis. Software evaluations were accomplished by performing HRV analysis on simulated and public congestive heart failure (CHF) data. Application of HRVAS included studying the effects of hyperaldosteronism on HRV in rats. Simulation and CHF results demonstrated that HRVAS was a dependable HRV analysis tool. Results from the rat hyperaldosteronism model showed that 5 of 26 HRV measures were statistically significant (p<0.05). HRVAS provides a useful tool for HRV analysis to researchers.


Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.