Electronic Theses and Dissertations

Identifier

1166

Date

2014

Date of Award

6-4-2014

Document Type

Thesis

Degree Name

Master of Science

Major

Physics

Concentration

Materials Science

Committee Chair

Mohamed Laradji

Committee Member

Omar Skalli

Committee Member

Pradhan Prabhakar

Abstract

Blebbing, a transition in cellular structures that produces cytoskeleton free protrusions of membrane, is a simple process with many causes.Using coarse grained molecular dynamics methods and the erythrocyte model, we attempt to survey these parameters using experimental results as a guide.After establishing the model's validity, with regard to established membrane mechanics, a mismatch parameter, s, is used to tie together the modeling and methods to make predictions about experimental behavior.Expansions to the model, like the weak adhesion parameter, Uadh and an explicit solvent, show promise in solving deficiencies and gaps in understanding the blebbing and vesiculation problems.The expansions and membrane mechanics are tied together to create a more complete picture of the blebbing-vesiculation cycle that affects erythrocytes and many other cells.

Comments

Data is provided by the student.

Library Comment

dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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