Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1β
Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), a widespread environmental contaminant, may elicit its effects by altering gene expression in susceptible cells. Five TCDD-responsive complementary DNA clones were isolated from a human keratinocyte cell line. One of these clones encodes plasminogen activator inhibitor-2, a factor that influences growth and differentiation by regulating proteolysis of the extracellular matrix. Another encodes the cytokine interleukin-1β. Thus, TCDD alters the expression of growth regulatory genes and has effects similar to those of other tumor-promoting agents that affect both inflammation and differentiation.
Sutter, T., Guzman, K., Dold, K., & Greenlee, W. (1991). Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1β. Science, 254 (5030), 415-418. https://doi.org/10.1126/science.1925598