Electrospun gelatin–arabinoxylan ferulate composite fibers for diabetic chronic wound dressing application
Blends of arabinoxylan ferulate (AXF) and gelatin (GEL) at 1:1, 2:1 and 4:1 mass ratios were electrospun into composite fibrous mats as a wound-healing drug delivery platform. The composite fibers were characterized in terms of morphology, tensile properties, pore size, porosity and molecular composition. The composite fibers showed excellent cytocompatibility. Silver was impregnated into GEL-AXF nanofibers, and it was slowly released, resulting in bacterial growth inhibition as confirmed by the Kirby–Bauer disk-diffusion assay. This work establishes an electrospun arabinoxylan fibrous material platform with the potential to treat chronic diabetic wounds.
International Journal of Polymeric Materials and Polymeric Biomaterials
Aduba, D., An, S., Selders, G., Yeudall, W., Bowlin, G., Kitten, T., & Yang, H. (2019). Electrospun gelatin–arabinoxylan ferulate composite fibers for diabetic chronic wound dressing application. International Journal of Polymeric Materials and Polymeric Biomaterials, 68 (11), 660-668. https://doi.org/10.1080/00914037.2018.1482466