Title

Measurement of glomerular filtration rate by dynamic contrast-enhanced magnetic resonance imaging using a subject-specific two-compartment model

Abstract

Measuring glomerular filtration rate (GFR) by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) as part of standard of care clinical MRI exams (e.g., in pediatric solid tumor patients) has the potential to reduce diagnostic burden. However, enthusiasm for this relatively new GFR test may be curbed by the limited amount of cross-calibration studies with reference GFR techniques and the vast variety of MR tracer model algorithms causing confusion on the choice of model. To advance MRI-based GFR quantification via improved GFR modeling and comparison with associated 99mTc-DTPA-GFR, 29 long-term Wilms' tumor survivors (19.0-43.3 years, [median 32.0 ± 6.0 years]) treated with nephrectomy, nonnephrotoxic chemotherapy ± radiotherapy underwent MRI with Gd-DTPA administration and a 99mTc-DTPA GFR test. For DCE-MRI-based GFR estimation, a subject-specific two-compartment (SS-2C) model was developed that uses individual hematocrit values, automatically defines subject-specific uptake intervals, and fits tracer-uptake curves by incorporating these measures. The association between reference 99mTc-DTPA GFR and MR-GFRs obtained by SS-2C, three published 2C uptake, and inflow-outflow models was investigated via linear regression analysis. Uptake intervals varied from 64 sec to 141 sec [96 sec ± 21 sec] and hematocrit values ranged from 30% to 49% [41% ± 4%]; these parameters can therefore not be assumed as constants in 2C modeling. Our MR-GFR estimates using the SS-2C model showed accordingly the highest correlation with 99mTc-DTPA-GFRs (R2 = 0.76, P < 0.001) compared with other models (R2-range: 0.36-0.66). In conclusion, SS-2C modeling of DCE-MRI data improved the association between GFR obtained by 99mTc-DTPA and Gd-DTPA DCE-MRI to such a degree that this approach could turn into a viable, diagnostic GFR assay without radiation exposure to the patient.

Publication Title

Physiological Reports

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