Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend
Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly(ethylene-co-vinyl acetate) (PEVA), or from a 50:50 blend of the two. The fibers were electrospun from chloroform solutions containing a small amount of methanol to solubilize the drug. The release of the tetracycline hydrochloride from these new drug delivery systems was followed by UV-VIS spectroscopy. Release profiles from the electrospun mats were compared to a commercially available drug delivery system, Actisite® (Alza Corporation, Palo Alto, CA), as well as to cast films of the various formulations. © 2002 Elsevier Science B.V. All rights reserved.
Journal of Controlled Release
Kenawy, E., Bowlin, G., Mansfield, K., Layman, J., Simpson, D., Sanders, E., & Wnek, G. (2002). Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. Journal of Controlled Release, 81 (1-2), 57-64. https://doi.org/10.1016/S0168-3659(02)00041-X