Nanovehicles: An efficient carrier for active molecules for entry into the cell


Nanovehicle as a carriers offer exclusive possibilities to overwhelmed cellular obstruction in order to improve the delivery of active substances, including the promising therapeutic biomacromolecules (i.e., nucleic acids, proteins). There are number of mechanisms lead to nanocarrier cellular internalization that is desperately affected by nanoparticles' physicochemical properties. The pharmacological actions of nanocarriers may be depends on the different paths cellular uptake and intracellular trafficking. In this article we are trying to foccus on several opportunities, starting with the phagocytosis pathway, which has followed in the treatment of certain cancer and various infectious diseases. On the other side, the non-phagocytic pathways accomplished various complex mechanisms, such as clathrin-mediated endocytosis, caveolae-mediated endocytosis and macropinocytosis, which are more challenging to control for pharmaceutical drug delivery scientists.

Publication Title

International Journal of Pharmaceutical Sciences Review and Research

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