Integration of Proteomics and Other Omics Data

Abstract

In recent biomedical studies, multidimensional profiling, which collects proteomics as well as other types of omics data on the same subjects, is getting increasingly popular. Proteomics, transcriptomics, genomics, epigenomics, and other types of data contain overlapping as well as independent information, which suggests the possibility of integrating multiple types of data to generate more reliable findings/models with better classification/prediction performance. In this chapter, a selective review is conducted on recent data integration techniques for both unsupervised and supervised analysis. The main objective is to provide the “big picture” of data integration that involves proteomics data and discuss the “intuition” beneath the recently developed approaches without invoking too many mathematical details. Potential pitfalls and possible directions for future developments are also discussed.

Publication Title

Methods in Molecular Biology

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