Title

Capture and detection of circulating tumor cells with magnetic-plasmonic hybrid nanoparticles

Abstract

This chapter describes recent work on the application of magnetic-plasmonic hybrid nanoparticles for capture and detection of circulating tumor cells. The chapter starts with synthesis and propeprties of anisotropic iron oxide-gold core-shell nanoparticles, followed by bioconjugation. An on-line flow system for dual magnetic separation and optical detection is also presented. The ability of the dual functional nanoparticles for capture and detection of circulating tumor cells is demonstrated using iron oxide-gold core-shell nanoparticles in the oval shape and spiked breast cancer cells in human whole blood. Both detection sensitivity and specificity are discussed.

Publication Title

Circulating Tumor Cells (CTCs): Detection Methods, Health Impact and Emerging Clinical Challenges

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