The origin of domestication genes in goats


Zhuqing Zheng, Northwest A&F UniversityFollow
Xihong Wang, Northwest A&F University
Ming Li, Northwest A&F University
Yunjia Li, Northwest A&F University
Zhirui Yang, Northwest A&F UniversityFollow
Xiaolong Wang, Northwest A&F University
Xiangyu Pan, Northwest A&F University
Mian Gong, Northwest A&F University
Yu Zhang, Northwest A&F UniversityFollow
Yingwei Guo, Northwest A&F University
Yu Wang, Northwest A&F University
Jing Liu, Northwest A&F University
Yudong Cai, Northwest A&F University
Qiuming Chen, Northwest A&F University
Moses Okpeku, Kunming Institute of Zoology Chinese Academy of Sciences
Moses Okpeku, Kunming Institute of Zoology Chinese Academy of Sciences
Moses Okpeku, Kunming Institute of Zoology Chinese Academy of Sciences
Licia Colli, Università Cattolica del Sacro Cuore, Campus di Piacenza e Cremona
Dawei Cai, Jilin University
Kun Wang, Northwestern Polytechnical UniversityFollow
Shisheng Huang, Northwest A&F University
Tad S. Sonstegard, Recombinetics, Inc.
Ali Esmailizadeh, Shahid Bahonar University of Kerman
Wenguang Zhang, Neimenggu Agricultural UniversityFollow
T. Tingting, Northwest A&F University
Yangbin Xu, Northwest A&F University
Naiyi Xu, Northwest A&F UniversityFollow
Yi Yang, College of Animal Sciences at Zhejiang University
Jianlin Han, Chinese Academy of Agricultural SciencesFollow
Jianlin Han, International Livestock Research Institute NairobiFollow
Lei Chen, Northwestern Polytechnical UniversityFollow
Joséphine Lesur, Museum National d'Histoire Naturelle
Kevin G. Daly, Trinity College Dublin


Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically.

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Science Advances