Electrospun chitosan guided bone regeneration membranes for delivery of simvastatin to stimulate osteogenesis


Statement of Purpose: Guided bone regeneration (GBR) membranes are used to augment healing by covering and protecting bone grafted spaces during the bone regeneration process and preventing soft tissue migration into the site. Electrospun chitosan membranes have a nanofibrous structure that mimics the native extracellular matrix. This supports cell attachment and growth and provides increased surface area for drug delivery. The porous structure of the membranes aid in the communication between osseous and epithelial tissue compartments and nutrient exchange while remaining cell occlusive, thereby serving as a good option for GBR membrane applications1. Simvastatin (SMV) is an anti-cholesterol drug that has been recently reported to promote bone growth and healing after local delivery, by antagonizing TNF-α inhibition of BMP-2, inhibiting osteoclast activity and improving angiogenesis2. This study examines the release of SMV from chitosan membranes subjected to four different treatments over a 28-day period and evaluates their cytocompatibility using mouse stromal cells.

Publication Title

Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

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