Novel thermo-responsive formation of a hydrogel by stereo-complexation between PLLA-PEG-PLLA and PDLA-PEG-PDLA block copolymers
Gel formation was discovered in an aqueous mixture of enantiomeric triblock copolymers, PLLA-PEG-PLLA and PDLA-PEG-PDLA. This system is characteristic in that an interesting sol-gel transition was induced by the stereo-complexation of the PLLA and PDLA segments of the block copolymers around 37°C. The process of gel formation was clearly monitored by the rheological change, and the responsibility of the stereo-complex formation for the gelation was confirmed by wide-angle X-ray scattering. The mechanism of this gel formation is discussed in relation to its potential applications.
Macromolecular Chemistry and Physics
Fujiwara, T., Mukose, T., Yamaoka, T., Yamane, H., Sakurai, S., & Kimura, Y. (2001). Novel thermo-responsive formation of a hydrogel by stereo-complexation between PLLA-PEG-PLLA and PDLA-PEG-PDLA block copolymers. Macromolecular Chemistry and Physics, 202 (11), 204-208. Retrieved from https://digitalcommons.memphis.edu/facpubs/1992