A secreted calreticulin protein in ixodid tick (Amblyomma americanum) saliva
A complementary DNA clone from salivary glands of feeding female Amblyomma americanum ticks has been characterized as encoding calreticulin. Calreticulin, a major endoplasmic reticulum (ER) calcium-binding protein, appears to be secreted in Amblyomma and Dermacentor saliva. Evidence is accummulating that calreticulin performs roles unrelated to calcium storage. Unlike most known calreticulins, tick-secreted calreticulin lacks the ER retention signal, KDEL. This is the first molecular cloning of a specific tick salivary gland protein. The finding of a secreted calreticulin in tick saliva suggests a role for calreticulin in blood feeding through host immunosuppression or antihemostasis. © 1995.
Journal of Insect Physiology
Jaworski, D., Simmen, F., Lamoreaux, W., & Coons, L. (1995). A secreted calreticulin protein in ixodid tick (Amblyomma americanum) saliva. Journal of Insect Physiology, 41 (4), 369-375. https://doi.org/10.1016/0022-1910(94)00107-R