Synthesis and adenosine receptor affinity of 7-β-D- Ribofuranosylxanthine
7-β-D-Ribofuranosylxanthine, a previously unreported isomer of xanthosine, was prepared in four steps from 7-benzylxanthine. The procedure, which involves the use of pivaloyloxymethyl groups to protect the xanthine ring, was also applied to preparation of some 1-N-alkyl derivatives of 7- ribosylxanthine. Adenosine receptor affinity for these compounds was determined. 7-β-D-Ribofuranosylxanthine was found to have higher affinity and greater selectivity for the A1 receptor than previously reported xanthine nucleotides, and to be a partial agonist.
Nucleosides and Nucleotides
Bridson, P., Lin, X., Melman, N., Ji, X., & Jacobson, K. (1998). Synthesis and adenosine receptor affinity of 7-β-D- Ribofuranosylxanthine. Nucleosides and Nucleotides, 17 (4), 759-768. https://doi.org/10.1080/07328319808004673