Copper localization in the duodenal mucosa of heterozygous tortoiseshell (Moto/+) female mice (Mus musculus)


The duodenal mucosa of normal (+/+) and heterozygous tortoiseshell (Moto/+) female mice was analysed by an ultrastructural histochemical copper localization technique. Copper was rarely detected along the duodenal microvilli of +/+ female mice. However, copper was localized on the surface of the brush border of the duodenal mucosa and within pinocytotic vesicles at the base of the microvilli of Moto/+ female mice. The mottled defect may involve a defective intestinal uptake of copper, as well as a faulty copper transport mechanism. © 1981, Cambridge University Press. All rights reserved.

Publication Title

Genetical Research