Pathogenic role of environmental toxins in immune-mediated liver diseases
Immune-mediated liver diseases contribute significantly to morbidity and mortality due to liver failure and the need for liver transplantation. The pathogenesis of the immune-mediated chronic liver diseases, primary sclerosing cholangitis, autoimmune hepatitis, and primary biliary cirrhosis, is poorly understood. Genetic susceptibility factors may play a role, but increasing attention is being given to the association between environmental factors and these diseases. The existence of such a relationship is supported by epidemiologic surveys, animal models, and geographic clustering analyses. Unearthing the cause of this association may provide insight into the pathogenesis of immune-mediated chronic liver diseases and autoimmunity. Copyright © Informa Healthcare USA, Inc.
Journal of Immunotoxicology
Stanca, C., Babar, J., Singal, V., Ozdenerol, E., & Odin, J. (2008). Pathogenic role of environmental toxins in immune-mediated liver diseases. Journal of Immunotoxicology, 5 (1), 59-68. https://doi.org/10.1080/15476910802019086