Divide and invade: The dynamic cytoskeleton of glioblastoma cells


This chapter first provides an overview of emerging concepts on how the cytoskeleton participates in the malignant behavior of cancer cells with an emphasis on glioblastomas (GBMs). Then, it reviews cytoskeletal proteins specific to GBMs versus normal brain cells, and what is known about the role of these proteins in motility and invasion. The potential of cytoskeletal proteins as therapeutic targets is also considered. The studies reviewed in this chapter have established that the cytoskeletal protein composition of GBMs differs extensively from that of normal astrocytes and/or lower-grade astrocytomas. Such studies can provide the basis to develop strategies to target cytoskeletal proteins other than tubulin to lead GBM cells to their demise.

Publication Title

Glioblastoma: Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies