Modeling developmental data using U-shaped threshold dose-response curves
This paper develops threshold models for developmental toxicity data. The distinguishing feature of these threshold models is their flexibility in modeling data below threshold with a U-shaped function if the data warrants. The method is applied to actual data from a developmental study which exhibits U-shaped behavior in early dose groups. Results from a simulation study demonstrate the flexibility of the threshold model to pick up on U-shaped trends in the data. In addition, the simulation study reveals important considerations in design of developmental studies. © 2006 Taylor & Francis.
Journal of Applied Statistics
Hunt, D., & Bowman, D. (2006). Modeling developmental data using U-shaped threshold dose-response curves. Journal of Applied Statistics, 33 (1), 35-47. https://doi.org/10.1080/02664760500389525