Clinical and Demographic Characteristics of Upper Limb Dystonia
Background: Knowledge of characteristics in upper limb dystonia remains limited, derived primarily from small, single-site studies. Objective: The objective of this study was to characterize demographic and clinical characteristics of upper limb dystonia from the Dystonia Coalition data set, a large, international, multicenter resource. Methods: We evaluated clinical and demographic characteristics of 367 participants with upper limb dystonia from onset, comparing across subcategories of focal (with and without dystonia spread) versus nonfocal onset. Results: Focal onset occurred in 80%; 67% remained focal without spread. Task specificity was most frequent in this subgroup, most often writer's cramp and affecting the dominant limb (83%). Focal onset with spread was more frequent in young onset (<21 years). Focal onset occurred equally in women and men; nonfocal onset affected women disproportionately. Conclusions: Upper limb dystonia distribution, focality, and task specificity relate to onset age and likelihood of regional spread. Observations may inform clinical counseling and design, execution, and interpretation of future studies. © 2020 International Parkinson and Movement Disorder Society.
Norris, S., Jinnah, H., Klein, C., Jankovic, J., Berman, B., Roze, E., Mahajan, A., & Espay, A. (2020). Clinical and Demographic Characteristics of Upper Limb Dystonia. Movement Disorders, 35 (11), 2086-2090. https://doi.org/10.1002/mds.28223