Lymphocyte activation by HIV-1 envelope glycoprotein
Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro. The lymphocyte surface protein CD4 has been identified as a receptor for HIV-1 and binds the viral envelope glycoprotein (gp120). In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility. © 1988 Nature Publishing Group.
Kornfeld, H., Cruikshank, W., Pyle, S., Berman, J., & Center, D. (1988). Lymphocyte activation by HIV-1 envelope glycoprotein. Nature, 335 (6189), 445-448. https://doi.org/10.1038/335445a0