Modeling Disorders of Movement
Human movement disorders can be modeled in flies, worms, zebrafish, mice, rats, nonhuman primates, and a variety of other vertebrate and invertebrate systems. However, human movement disorders are best studied in humans. Moreover, bioinformatics and computational tools can obviate the use of animal model systems. In general, model systems will rarely emulate all of the clinical, systems, molecular, and cellular features of the corresponding human disease. On the other hand, animal models can be used to address critical questions regarding the network and cellular pathobiology of human movement disorders that cannot be tackled by alternative means. In addition, unbiased study of model systems can beget novel insights into sensorimotor networks and cell biology with impact beyond the domain of movement disorders.
Movement Disorders: Genetics and Models: Second Edition
LeDoux, M. (2015). Modeling Disorders of Movement. Movement Disorders: Genetics and Models: Second Edition, 23-43. https://doi.org/10.1016/B978-0-12-405195-9.00002-0