Thermoregulatory Dysfunction in Parkinson's Disease


Homeotherms, such as humans with Parkinson's disease, must maintain core body temperature in a narrow range in the face of fluctuating environmental surroundings and endogenous heat production. A complex and highly integrated collection of autonomic, endocrine, and behavioral responses are involved in the maintenance of core temperature. Dopaminergic innervation of the preoptic and anterior hypothalamus plays an important role in the central nervous system's control of body temperature. Due to a combination of central dopamine deficiency and peripheral autonomic dysfunction, individuals with Parkinson's disease may experience heat and/or cold intolerance and paroxysmal hyperhidrosis. Sudomotor dysfunction in Parkinson's disease can be documented with the sympathetic skin response and quantitative sudomotor axon reflex and thermoregulatory sweat tests. © Springer Science+Business Media New York 2013.

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Milestones in Drug Therapy