Electronic Theses and Dissertations

Identifier

1349

Date

2015

Document Type

Thesis

Degree Name

Master of Science

Major

Electrical and Computer Engr

Concentration

Electrical Engineering

Committee Chair

Bashir I Morshed

Committee Member

Eddie L Jacobs

Committee Member

Warren O Haggard

Abstract

In recent years, pharmaceutical research has seen a surge in various smart drug delivery systems (DDS) that attempt dosage control and drug localization, thereby granting enhanced therapeutic capabilities and flexibility to healthcare providers. Some of them used a stimuli to modify the drug release profile from DDS. In this work, chitosan microbeads embedded with magnetic nanoparticles were loaded with tetracycline (tet.) antibiotic and stimulated by an alternating magnetic field for 60 min. The spectrophotometric analysis of the supernatant from these stimulated samples showed a significantly higher release of tet., as compared to the control samples, which were subjected to exact same environment without the stimulation. Interestingly, the release was higher only during the stimulation period, the resting period showed comparable amount of tet. released in the waiting span. The results indicate promising possibility of a smart controllable DDS by magnetic excitation.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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