Electronic Theses and Dissertations

Identifier

2698

Date

2016

Document Type

Thesis

Degree Name

Master of Science

Major

Biomedical Engineering

Committee Member

Amy de Jongh Curry

Committee Member

Judith Soberman

Committee Member

Erno Lindner

Abstract

Myocardial infarction (MI), commonly known as a heart attack, is the irreparable necrosis of the cardiac tissue due to sustained ischemia. MI may lead to heart failure. Despite advances in treatments, the number of patients with heart failure is increasing. Engineered heart tissue, EHT, could offer an innovative approach to treating areas of infarcted cardiac tissue. Ideally, EHT should integrate and function with the native heart without causing a higher risk for complications. The purpose of this study is to design a system to identify potentially arrhythmogenic sites in EHT. Specifically, an electrode array complete with DAQ system and data analysis program was developed to record electrical propagation and interpret conduction velocity (CV) speeds to identify areas of slow conduction. This system has the ability to analyze the activation times, calculate CV vector fields, and identify areas within the mapping window that display slow CV speeds and are considered arrhythmic-prone.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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