Electronic Theses and Dissertations
Identifier
4823
Date
2016
Document Type
Thesis
Degree Name
Master of Science
Major
Clinical Nutrition
Committee Chair
Marie van der Merwe
Committee Member
Richard Bloomer
Committee Member
Andrew Liu
Abstract
The goal was to determine if a high fat diet given in a time restricted fashion can protect against obesity and inflammatory mediators. 12 week old C57BL/6 male mice were assigned to either a standard chow diet or a diet containing 45% fat. The high fat diet was provided ad libitum or in a time restricted fashion, either during the first of the second half of the active phase for 8 weeks. Time restricted meal intake reduced body mass gain, adiposity, glucose intolerance and cholesterol levels in mice fed a high fat diet. Mice fed a high fat diet, even on a time restricted meal pattern, resulted in increased tumor necrosis factor-a, fatty liver development and adipocyte hypertrophy suggesting time restricted feeding can protect against obesity, but does not protect against inflammation. These results suggest that a high fat diet can induce inflammation even in the absence of weight gain.
Library Comment
Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Recommended Citation
Crone, Laura Brooks, "Metabolic Alteration Induced by Time Restricted Feeding at Different Points in the Circadian Cycle" (2016). Electronic Theses and Dissertations. 1542.
https://digitalcommons.memphis.edu/etd/1542
Comments
Data is provided by the student.